Status: Active

CCU109

There is variation in the type of heart attack management people who are frail (when the body is weaker and less able to recover from illness) or who have kidney disease receive when having a heart attack. This is because… Read more

CCU104

Stroke and dementia are among the leading causes of death and disability in England. Research suggests that COVID-19 may increase the risk of both conditions. However, there is limited understanding of how COVID-19 interacts with vascular risk factors and medications… Read more

CCU103

The COVID-19 pandemic had a major impact on people with heart disease. They faced a higher risk of death and serious health problems. At the same time, healthcare services changed, with more remote check-ups being used, and changes in prescriptions… Read more

CCU099

People with severe or complex mental illness (SCMI) are more likely to have physical illnesses like heart disease than people without SCMI and are more likely to have difficulties accessing health care. For example, we know that people with SCMI… Read more

CCU070

Because of the impact of COVID-19 there is strain on research staff doing diabetes research in hospitals and GP surgeries across the UK. Using new trial methods, in which the trial coordinating office communicates directly with trial participants by telephone,… Read more

CCU106

Kidney disease is a major health issue, affecting ~20% of adults over the age of 35 in England. Heart disease – including heart attacks, heart failure and stroke – is the commonest cause of death in patients with kidney disease,… Read more

CCU105

Heart attacks are serious, can be fatal and are common. Because of major advances in treatment, many more people nowadays survive a heart attack. However, people who survive a heart attack have a higher chance of developing other conditions later… Read more

CCU101

Existing evidence shows that most people would prefer to avoid admissions to hospital in the final months of life and to die at home. People who live in deprived areas are more likely to have more emergency hospital admissions in… Read more

CCU100

Fatty liver disease (FLD) is a chronic liver condition characterised by fat accumulation in the liver. It is also known by various related terms such as non-alcoholic fatty liver disease (NAFLD) or metabolic associated steatotic liver disease (MASLD). FLD is… Read more

CCU097

Type 2 diabetes is one of the most common chronic diseases in the UK. With ~3.9 million people with diabetes in the UK, as of 2019, the number is increasing. Type 2 diabetes is when an individual is unable to… Read more

CCU095

Artificial intelligence (AI) refers to computer systems that aim to perform tasks typically requiring human intelligence, such as problem-solving and decision-making. AI is a rapidly growing area of technology and innovation, sparking excitement about its potential for improving healthcare outcomes. Read more

CCU094

Coronary heart disease and stroke are the main cause of death and disability in the world. Some patients with coronary heart disease and stroke have other illnesses that do not primarily involve the heart and vessels, such as pancreatic disorders,… Read more

CCU093

Diabetes (a condition where blood sugar level is too high) is associated with key complications such as cardiovascular, kidney, eye and foot conditions. However, people with diabetes may also be more likely to develop other conditions not necessarily flagged as… Read more

CCU096

Obesity has been declared a worldwide epidemic by the World Health Organisation (WHO) and the number of people living with this condition continues to rise worldwide. It is a complex, chronic, and progressive condition, which substantially affects health, quality of… Read more

CCU092

Many public health policies (i.e. decisions relating to healthcare for the whole population) could be altered to improve health outcomes, value for money, or both. For example, in heart disease we could change the timing or frequency of risk assessments. Read more

CCU090

Aortic valve stenosis is a chronic heart condition where there is an abnormal narrowing of the aortic valve. This impacts the heart’s ability to efficiently pump blood to the rest of the body. Transcatheter aortic valve implantation (TAVI) offers treatment… Read more

CCU089

The COVID pandemic halted elective surgery. Over 7.3 million patients are now on the waiting list for elective (planned) operations and some patients have waited over 78 weeks. Delays to treatment can have a major impact on patient health, well-being… Read more

CCU088

Iron deficiency anaemia (IDA) is a condition where a lack of iron in the body leads to a reduction in the number of red blood cells. Iron is used to produce red blood cells, which help store and carry oxygen in… Read more

CCU087

There is increasing prevalence of diabetes, obesity, cardiovascular disease, and heart failure across most populations globally. The increase in diabetes includes both type 1 and type 2 diabetes. It is recognised by doctors that cardiovascular disease is commonly identified in… Read more

CCU086

During the COVID-19 pandemic, it became apparent that COVID-19 infection caused a range of issues within the nervous system including stroke, encephalopathy and peripheral neuropathy. We have also seen similar neurological complications in previous pandemics including Spanish flu (1918) and… Read more

CCU080

During the COVID-19 pandemic, priority for imaging tests, such as x-ray, ultrasound, and scans such as computed tomography (CT) and magnetic resonance imaging (MRI), was often given to assess patients with COVID-19. As a consequence, many routine imaging tests for… Read more

CCU085

When someone has a stroke, they are taken to hospital for emergency treatment and rehabilitation. We wish to understand the long-term consequences of stroke on the patient and to the NHS (especially the length of time patients spend in hospital… Read more

CCU084

Each year, the number of new strokes diagnosed in older people has been decreasing. However, even before COVID-19 hit, the number of strokes in people aged under 55 had doubled in the last 10 years. Researchers found that both getting… Read more

CCU083

The COVID-19 pandemic has affected the way we deliver care for cardiology patients, especially those presenting with heart attacks. While the pandemic is now deemed to be over, its indirect effect in terms of disruption to services persists. Patients with… Read more

CCU082

Pulmonary arterial hypertension (PAH) is a serious condition that often affects people born with heart defects (congenital heart disease, CHD), even after surgery to repair their heart problem. This condition can make it hard for patients to breathe and do… Read more

CCU077

Cancer patients are at a heightened risk of heart attacks, formally known as acute coronary syndrome (ACS). Whilst the gold standard therapy for ACS is percutaneous coronary intervention (PCI), using a stent to open narrowed or blocked arteries, for reduction… Read more

CCU081

People with autoimmune rheumatic diseases, where the immune system attacks its own body, are more likely to have heart attacks and other cardiovascular (CV) diseases than the general population. Idiopathic inflammatory myopathy (IIM) is a rare autoimmune disease where both… Read more

CCU079

COVID-19 infection (also known as Covid, or severe acute respiratory syndrome coronavirus 2 infection) is mostly mild in children and young people. When someone continues to have symptoms weeks after their COVID-19 infection, this is known as long-COVID. Previous studies,… Read more

CCU078

UPDATE: This research project is currently paused pending a review. Further updates will be provided in due course. Who gets ill, when, and with which diseases and outcomes, are key questions for individuals, clinicians and healthcare systems. The COVID-19 pandemic… Read more

CCU057

People with severe mental illnesses (SMI) such as schizophrenia and bipolar affective disorders have a life expectancy 15-20 years lower than the general population, with two thirds of deaths from preventable chronic conditions such as cardiovascular and cerebrovascular disease, cancers… Read more

CCU074

This project aims to improve the design of clinical studies of intracerebral haemorrhage (ICH), a type of stroke caused by bleeding in the brain. It’s important that sufficient numbers of people take part in a research… Read more

CCU058

The NHS has created a talking therapy service called Improving Access to Psychological Therapies (IAPT) to help people with depression and anxiety. IAPT has recently been offered to people with long-term physical disorders that have depression and anxiety. We do… Read more

CCU059

An estimated 14 million people in England are living with two or more chronic conditions, referred to Multiple Long-Term Conditions (MLTC). We know that people living with MLTC have a higher risk of being admitted to hospital and of dying… Read more

CCU076

COVID-19 infection may become an annual winter virus and follow a clear seasonal pattern, like influenza. Environmental factors, such as extremes in temperature and pollution, could make it easier for the COVID-19 infection to increase the chances of getting a… Read more

CCU075

Patients and healthcare professionals alike are concerned about the side effects* of steroids, especially the increased chance of developing osteoporosis, diabetes, and cardiovascular diseases (van der Goes 2009). Yet, patients with vasculitis (a collection of rare conditions of inflamed blood… Read more

CCU071

Cardiovascular disease (CVD) and its risk factors remain the leading cause of death and illness in the UK, causing 1 in 4 deaths in England. The Covid-19 pandemic has added to the burden and the urgency in identifying risk factors… Read more

CCU060

This winter, COVID, influenza and their indirect effects on chronic disease care (particularly cardiovascular disease, CVD) probably represent the greatest challenges for the NHS. COVID and influenza can have direct (e.g. hospitalisation and mortality), indirect (e.g. reduced CVD procedures) and… Read more

CCU072

Healthcare planners need important epidemiological metrics for vascular diseases like heart attack and stroke. For example, they need to know how often people have diseases of different types (‘incidence’), how severe these diseases are (‘case fatality’), and how many people… Read more

CCU069

CCU069
Heart and diabetes related problems are the number one cause of death in the world. Also known as cardiometabolic diseases, many of them are common and well-known. Some however are rare or found in less than 1 in 2,000 people. Read more

CCU066

National Institute for Health and Care Excellence (NICE) guidelines clearly state how to treat most people hospitalised with a heart attack, particularly people hospitalised for a heart attack involving a complete blockage of one of the heart’s main blood vessels… Read more

CCU064

During the COVID-19 pandemic, healthcare providers had to quickly adapt their approach to screening, diagnosing, and managing high blood sugar levels in pregnancy, known as gestational diabetes (GDM). To minimise the risk of viral exposure, care providers made changes to… Read more

CCU063

With over one billion people on the move globally, the healthcare of international migrants is increasingly important in the design and delivery of health services. COVID-19 had a greater impact on minoritised ethnic populations and migrants in England. However, we… Read more

CCU053

The medications called Sodium glucose co-transporter-2 inhibitors (SGLT2i) were developed as a diabetes drug but are now being used in people without diabetes who have heart failure or kidney disease.  In people with diabetes, infection with COVID-19 increases the risk… Read more

CCU052

Asthma, interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are chronic respiratory diseases that cause substantial disability and are associated with increased risk of death. Past studies have usually provided high-level snapshot pictures of their frequencies and associated… Read more

CCU049

Most analysis on how people use healthcare services is a ‘rear-view mirror sport’, meaning that analysis is performed after the event. We aim to change it to more of a ‘through-the-windscreen sport’ to demonstrate healthcare utilisation and how we can… Read more

CCU046

Severe mental illness (SMI), which includes schizophrenia, bipolar disorder and major depression, affects about one in ten people. People with SMI die 10-20 years sooner than the general population, largely due to poorer physical health, in particular conditions that affect… Read more

CCU045

Heart Failure (HF) continues to be a major global health-care problem. Despite some recent advances  in therapy it still has an unacceptably high mortality rate. It is estimated that, to date, more than 38 million people suffer from HF world-wide. Read more

CCU043

Over the last 24 months, evidence has consistently reported that certain long-term diseases, such as diabetes,  are very common in people with COVID-19. Diabetes has also been linked with an increased risk of severity (i.e. worsened symptoms) and mortality (i.e. Read more

CCU038

Despite advances in modern medicine, a significant proportion of those admitted to intensive care will unfortunately not survive. The reasons why certain patients do better or worse are complex and remain poorly understood, but include the interplay between a patient’s… Read more

CCU037

This research project is awarded through a funding call by Health Data Research UK and the Alan Turing Institute as part of the wider Data and Connectivity National Core Study. Further details on this project are available here. Read more

CCU036

This research project is awarded through a funding call by Health Data Research UK and the Alan Turing Institute as part of the wider Data and Connectivity National Core Study. Further details on this project are available here. Read more

CCU032

Heart Failure (HF) is a complex set of conditions that results in the heart performing less well than it did – it is no longer pumping blood as well as it would in perfect health. HF affects around 1 million… Read more

CCU030

People living with intellectual and developmental disabilities (i.e. intellectual disabilities and/or autism) are more likely to be admitted to hospital and die from infection with COVID-19. We do not know why people living with intellectual and developmental disabilities experience poorer… Read more

CCU029

During the first year of the COVID-19 pandemic, the risks to children related to COVID-19 infection were considered very low. Nonetheless, a subset of children with severe infections were admitted to hospital, required intensive care and experienced longer-term health issues. Read more

CCU028

Angina is a chronic heart condition that has a substantial impact on our health and social services, and on the population, society and the economy. Treatment with a coronary stent (thin metal tube) is intended to relieve angina, and around… Read more

CCU023

COVID-19 vaccine rollout in the UK has been very successful. However, how long immunity from SARS-Cov-2 – the virus that causes COVID-19 – will last with vaccines is unknown. It is also unknown if new vaccines will need to be… Read more

CCU022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new virus responsible for the COVID-19 pandemic, which has caused many deaths worldwide. We are worried that some long-term (“chronic”) diseases, such as heart disease and diabetes, can worsen COVID-19… Read more

CCU019

We know individuals with underlying health conditions have greater risk of developing severe COVID-19 and ending up with poorer outcomes. That is why governments and public health services have been providing dedicated and prioritised protections for these more clinically vulnerable… Read more

CCU018

COVID-19 infection during pregnancy may increase the risk of cardiovascular health problems related to pregnancy and giving birth. Small hospital-based studies have suggested a relationship between COVID-19 infection during pregnancy and severe complications for mothers and their babies. However, since… Read more

CCU016

People living with dementia have been amongst the hardest hit during the COVID-19 pandemic. A group of drugs called ‘antipsychotics’ are sometimes used to treat distress and agitation in people living with dementia. However, there is evidence to suggest that… Read more

CCU014

Cardiovascular disease (CVD, including heart attacks and strokes) remains one of the leading causes of death in the UK. There are a number of conditions that commonly increase an individual’s risk of developing CVD. Some of these conditions, such as… Read more

CCU013

When a patient visits their GP or is admitted into hospital, information about their symptoms, diagnosis, lab test results and prescriptions is inputted and stored in ‘Electronic Health Records’ (‘EHRs’). These EHR’s are a valuable resource for researchers and clinicians… Read more

CCU010

Since the first case of COVID-19 in the UK in January 2020, there have been nearly 4 million cases reported. Whilst most people have recovered with only mild to moderate symptoms, others have more severe symptoms requiring admission to hospital. Read more

CCU007

Cardiac surgery is a necessary life-extending/saving procedure required by many adults and children every day in the UK. Despite it being prioritised during the COVID-19 pandemic, the true impact of the latter on case volume and outcome are unknown. The… Read more

CCU005

Since the COVID-19 pandemic, there has been rapid progress made towards the availability and accessibility of national healthcare data for research. Consequently, for the first time we are analysing data from over 65 million patients across the UK to help… Read more

CCU004

Cardiovascular disease (CVD), comprising mostly heart attacks and strokes, is one of the UK’s leading causes of death and disability. It is far better and cheaper to prevent CVD than to treat patients after they get sick. Read more

CCU003

Coronavirus (COVID-19) directly impacts individuals who become infected with the virus. It can also influence people’s healthcare decisions (such as deciding not to attend medical appointments for fear of infection). In addition, hospitals have sometimes had to prioritise treatment of… Read more

CCU002

Coronavirus infection (‘COVID-19’) or vaccination against coronavirus might increase a person’s chance of having a stroke, heart attack or clot in the deep veins or lungs (‘blood vessel diseases’). During the COVID-19 pandemic, some doctors have looked after patients with… Read more

CCU001

ACE inhibitors and angiotensin receptor blockers are drugs that are commonly used to lower high blood pressure. These drugs may affect the ability of the coronavirus to enter cells of the body and cause COVID-19. We plan to investigate whether… Read more