Topic: Whole population

CCU105

Heart attacks are serious, can be fatal and are common. Because of major advances in treatment, many more people nowadays survive a heart attack. However, people who survive a heart attack have a higher chance of developing other conditions… Read more

CCU100

Fatty liver disease (FLD) is a chronic liver condition characterised by fat accumulation in the liver. It is also known by various related terms such as non-alcoholic fatty liver disease (NAFLD) or metabolic associated steatotic liver disease (MASLD). FLD… Read more

CCU097

Type 2 diabetes is one of the most common chronic diseases in the UK. With ~3.9 million people with diabetes in the UK, as of 2019, the number is increasing. Type 2 diabetes is when an individual is unable… Read more

CCU095

Artificial intelligence (AI) refers to computer systems that aim to perform tasks typically requiring human intelligence, such as problem-solving and decision-making. AI is a rapidly growing area of technology and innovation, sparking excitement about its potential for improving healthcare… Read more

CCU093

Diabetes (a condition where blood sugar level is too high) is associated with key complications such as cardiovascular, kidney, eye and foot conditions. However, people with diabetes may also be more likely to develop other conditions not necessarily flagged… Read more

CCU096

Obesity has been declared a worldwide epidemic by the World Health Organisation (WHO) and the number of people living with this condition continues to rise worldwide. It is a complex, chronic, and progressive condition, which substantially affects health, quality… Read more

CCU090

Aortic valve stenosis is a chronic heart condition where there is an abnormal narrowing of the aortic valve. This impacts the heart’s ability to efficiently pump blood to the rest of the body. Transcatheter aortic valve implantation (TAVI) offers… Read more

CCU087

There is increasing prevalence of diabetes, obesity, cardiovascular disease, and heart failure across most populations globally. The increase in diabetes includes both type 1 and type 2 diabetes. It is recognised by doctors that cardiovascular disease is commonly identified… Read more

CCU080

During the COVID-19 pandemic, priority for imaging tests, such as x-ray, ultrasound, and scans such as computed tomography (CT) and magnetic resonance imaging (MRI), was often given to assess patients with COVID-19. As a consequence, many routine imaging tests… Read more

CCU083

The COVID-19 pandemic has affected the way we deliver care for cardiology patients, especially those presenting with heart attacks. While the pandemic is now deemed to be over, its indirect effect in terms of disruption to services persists. Read more

CCU079

COVID-19 infection (also known as Covid, or severe acute respiratory syndrome coronavirus 2 infection) is mostly mild in children and young people. When someone continues to have symptoms weeks after their COVID-19 infection, this is known as long-COVID. Previous… Read more

CCU078

UPDATE: This research project is currently paused pending a review. Further updates will be provided in due course. Who gets ill, when, and with which diseases and outcomes, are key questions for individuals, clinicians and healthcare systems. The… Read more

CCU059

An estimated 14 million people in England are living with two or more chronic conditions, referred to Multiple Long-Term Conditions (MLTC). We know that people living with MLTC have a higher risk of being admitted to hospital and of… Read more

CCU072

Healthcare planners need important epidemiological metrics for vascular diseases like heart attack and stroke. For example, they need to know how often people have diseases of different types (‘incidence’), how severe these diseases are (‘case fatality’), and how many… Read more

CCU069

Heart and diabetes related problems are the number one cause of death in the world. Also known as cardiometabolic diseases, many of them are common and well-known. Some however are rare or found in less than 1 in 2,000… Read more

CCU068

CCU068
Congenital heart disease (CHD) is the commonest birth defect, affecting just under 1% of the population – at least 700,000 people in the UK. Work we have done in UK general practice patients, using information predating mass COVID vaccination,… Read more

CCU066

National Institute for Health and Care Excellence (NICE) guidelines clearly state how to treat most people hospitalised with a heart attack, particularly people hospitalised for a heart attack involving a complete blockage of one of the heart’s main blood… Read more

CCU064

During the COVID-19 pandemic, healthcare providers had to quickly adapt their approach to screening, diagnosing, and managing high blood sugar levels in pregnancy, known as gestational diabetes (GDM). To minimise the risk of viral exposure, care providers made… Read more

CCU061

There is limited information describing the different ways people who have COVID-19 are managed. Different people have different treatments, sometimes no treatment at all. It is not known if outcomes (death or re-hospitalisation or other complications) vary depending upon… Read more

CCU056

Aortic stenosis (AS), or narrowing of the aortic valve, is the commonest reason for having heart valve surgery in the west, that causes poor quality of life and death, if untreated. It affects ~1-in-20 adults aged >65, but the… Read more

CCU052

Asthma, interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are chronic respiratory diseases that cause substantial disability and are associated with increased risk of death. Past studies have usually provided high-level snapshot pictures of their frequencies and… Read more

CCU051

The benefits of Covid-19 vaccinations are well-known; they reduce the risk of infection and lower the risk of serious illness or death associated with Covid-19. Evidence in England and Scotland suggests rates of COVID-19 hospitalisation and COVID-19 death are… Read more

CCU047

Epilepsy, a tendency to repeated seizures, is common, affecting 600,000 people in the UK of all ages.  People with epilepsy face significant physical health, mental health and social problems. Small studies have shown that people with epilepsy may have… Read more

CCU046

Severe mental illness (SMI), which includes schizophrenia, bipolar disorder and major depression, affects about one in ten people. People with SMI die 10-20 years sooner than the general population, largely due to poorer physical health, in particular conditions that… Read more

CCU045

Heart Failure (HF) continues to be a major global health-care problem. Despite some recent advances  in therapy it still has an unacceptably high mortality rate. It is estimated that, to date, more than 38 million people suffer from HF… Read more

CCU044

At the beginning of the COVID-19 pandemic, the UK government instituted a shielding policy for vulnerable groups, assuming that shielding would protect them from severe illness and/or death from COVID-19. However, recent research found worse COVID-19 outcomes amongst vulnerable… Read more

CCU043

Over the last 24 months, evidence has consistently reported that certain long-term diseases, such as diabetes,  are very common in people with COVID-19. Diabetes has also been linked with an increased risk of severity (i.e. worsened symptoms) and mortality… Read more

CCU037

This research project is awarded through a funding call by Health Data Research UK and the Alan Turing Institute as part of the wider Data and Connectivity National Core Study. Further details on this project are available here. Read more

CCU032

Heart Failure (HF) is a complex set of conditions that results in the heart performing less well than it did – it is no longer pumping blood as well as it would in perfect health. HF affects around 1… Read more

CCU028

Angina is a chronic heart condition that has a substantial impact on our health and social services, and on the population, society and the economy. Treatment with a coronary stent (thin metal tube) is intended to relieve angina, and… Read more

CCU020

Antithrombotics are blood thinning medications that are used to treat a range of cardiovascular diseases. Atrial fibrillation (AF) is one such disease, and is the most common disturbance of heart rhythm and a common cause of stroke. In individuals who… Read more

CCU019

We know individuals with underlying health conditions have greater risk of developing severe COVID-19 and ending up with poorer outcomes. That is why governments and public health services have been providing dedicated and prioritised protections for these more clinically… Read more

CCU013

When a patient visits their GP or is admitted into hospital, information about their symptoms, diagnosis, lab test results and prescriptions is inputted and stored in ‘Electronic Health Records’ (‘EHRs’). These EHR’s are a valuable resource for researchers and… Read more

CCU005

Since the COVID-19 pandemic, there has been rapid progress made towards the availability and accessibility of national healthcare data for research. Consequently, for the first time we are analysing data from over 65 million patients across the UK to… Read more

CCU001

ACE inhibitors and angiotensin receptor blockers are drugs that are commonly used to lower high blood pressure. These drugs may affect the ability of the coronavirus to enter cells of the body and cause COVID-19. We plan to investigate… Read more