Fatty liver disease (FLD) is a chronic liver condition characterised by fat accumulation in the liver. It is also known by various related terms such as non-alcoholic fatty liver disease (NAFLD) or metabolic associated steatotic liver disease (MASLD). FLD is… Read more

Diabetes (a condition where blood sugar level is too high) is associated with key complications such as cardiovascular, kidney, eye and foot conditions. However, people with diabetes may also be more likely to develop other conditions not necessarily flagged as… Read more

Obesity has been declared a worldwide epidemic by the World Health Organisation (WHO) and the number of people living with this condition continues to rise worldwide. It is a complex, chronic, and progressive condition, which substantially affects health, quality of… Read more

The COVID pandemic halted elective surgery. Over 7.3 million patients are now on the waiting list for elective (planned) operations and some patients have waited over 78 weeks. Delays to treatment can have a major impact on patient health, well-being… Read more

There is increasing prevalence of diabetes, obesity, cardiovascular disease, and heart failure across most populations globally. The increase in diabetes includes both type 1 and type 2 diabetes. It is recognised by doctors that cardiovascular disease is commonly identified in… Read more

During the COVID-19 pandemic, it became apparent that COVID-19 infection caused a range of issues within the nervous system including stroke, encephalopathy and peripheral neuropathy. We have also seen similar neurological complications in previous pandemics including Spanish flu (1918) and… Read more

Cancer patients are at a heightened risk of heart attacks, formally known as acute coronary syndrome (ACS). Whilst the gold standard therapy for ACS is percutaneous coronary intervention (PCI), using a stent to open narrowed or blocked arteries, for reduction… Read more

COVID-19 infection (also known as Covid, or severe acute respiratory syndrome coronavirus 2 infection) is mostly mild in children and young people. When someone continues to have symptoms weeks after their COVID-19 infection, this is known as long-COVID. Previous studies,… Read more

UPDATE: This research project is currently paused pending a review. Further updates will be provided in due course. Who gets ill, when, and with which diseases and outcomes, are key questions for individuals, clinicians and healthcare systems. The COVID-19 pandemic… Read more

People with severe mental illnesses (SMI) such as schizophrenia and bipolar affective disorders have a life expectancy 15-20 years lower than the general population, with two thirds of deaths from preventable chronic conditions such as cardiovascular and cerebrovascular disease, cancers… Read more

This project aims to improve the design of clinical studies of intracerebral haemorrhage (ICH), a type of stroke caused by bleeding in the brain. It’s important that sufficient numbers of people take part in a research… Read more

An estimated 14 million people in England are living with two or more chronic conditions, referred to Multiple Long-Term Conditions (MLTC). We know that people living with MLTC have a higher risk of being admitted to hospital and of dying… Read more

Healthcare planners need important epidemiological metrics for vascular diseases like heart attack and stroke. For example, they need to know how often people have diseases of different types (‘incidence’), how severe these diseases are (‘case fatality’), and how many people… Read more

Heart and diabetes related problems are the number one cause of death in the world. Also known as cardiometabolic diseases, many of them are common and well-known. Some however are rare or found in less than 1 in 2,000 people. Read more

Congenital heart disease (CHD) is the commonest birth defect, affecting just under 1% of the population – at least 700,000 people in the UK. Work we have done in UK general practice patients, using information predating mass COVID vaccination, has… Read more

National Institute for Health and Care Excellence (NICE) guidelines clearly state how to treat most people hospitalised with a heart attack, particularly people hospitalised for a heart attack involving a complete blockage of one of the heart’s main blood vessels… Read more

This research project is awarded through a funding call by Health Data Research UK and the Alan Turing Institute as part of the wider Data and Connectivity National Core Study. Further details on this project are available here. Read more

People living with intellectual and developmental disabilities (i.e. intellectual disabilities and/or autism) are more likely to be admitted to hospital and die from infection with COVID-19. We do not know why people living with intellectual and developmental disabilities experience poorer… Read more

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new virus responsible for the COVID-19 pandemic, which has caused many deaths worldwide. We are worried that some long-term (“chronic”) diseases, such as heart disease and diabetes, can worsen COVID-19… Read more

Since the first case of COVID-19 in the UK in January 2020, there have been nearly 4 million cases reported. Whilst most people have recovered with only mild to moderate symptoms, others have more severe symptoms requiring admission to hospital. Read more