Matt Sydes

Matt Sydes


Professor Matt Sydes is the BHF Data Science Centre Associate Director and Theme Lead for Clinical Trials.

The focus for Matt’s theme is to develop platforms for efficient, cost-effective trials, using routine health data to recruit and follow patients with cardiovascular conditions.


Matt is responsible for co-leading MRC Clinical Trials Unit at UCL’s Trial Conduct Methodology programme. This work is to develop evidence-based ways to improve how clinical trials are run.

He is connected into HDR UK’s national Clinical Trials Theme, and is also 20% seconded to lead the Data-Enabled Trials theme for the BHF Data Science Centre.

Particular areas of methodological interest include: the use of routinely-collected electronic health records (EHR) to support and run trials; running academic-led trials with a view to regulatory use and submission; proportionate and efficient monitoring of clinical trial; implementation of novel designs into practice, particularly platform / master protocols; better clinical trial data sharing; and communication of trial findings.

Matt teaches on the UCL Institute of Clinical Trials and Methodology’s MSc in Clinical Trials and supervises a number of PhD and MSc students. Matt leads UCL’s short course on Data Monitoring Committees and has served on many Independent DMCs and Trial Steering Committees (TSCs) for national and international trials.

Matt chairs the Scientific Committee for ICTMC 2022, the next International Clinical Trials and Methodology Conference, and is on the executive committee for the NIHR-MRC Trials Methodology Research Partnership (TMRP). He sits on several funding panels, including MRC’s Better Methods Better Research.